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What’s new with the AMA CPT code set for 2025

Explore the American Medical Association’s 2025 CPT code changes — plus essential implementation strategies practices can use to boost revenue and ensure compliance.

Physician who just read about AMA CPT changes for 2025

Key Takeaways

  • The 2025 AMA CPT code set introduces 270 new codes, deletes 112, and revises 38, with significant changes in cardiology, general surgery, radiology, telemedicine, and AI-assisted procedures.
  • Notable updates include new telemedicine codes, revised remote patient monitoring requirements, and codes for AI analysis, reflecting the shift toward digital and remote healthcare.
  • To prepare, providers should update CPT manuals, adjust EHR systems, communicate with payers about coverage, and educate staff on relevant code changes to ensure compliance and optimize reimbursement.

Each year, the healthcare industry embraces new and exciting medical innovations, technologies, and cutting-edge procedures. And each year, the American Medical Association (AMA) updates the Current Procedural Terminology (CPT®) code set to reflect these important changes that impact patient care and reimbursement. These CPT code changes allow medical practices to capture and receive payment for the critical work they do. 

Medical coders, physicians, clinical documentation improvement specialists, and anyone else who uses medical codes on a regular basis can access key updates of the CPT code set and implementation tips through this guide.

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Key changes in the 2025 CPT code set

Effective January 1, 2025, the CPT code set will undergo its annual transformation. Precisely how many CPT changes are there for 2025? This time around, the annual update includes 270 new codes, 112 deletions, and 38 revisions.

The 2025 update includes 270 new codes, 112 deletions, and 38 revisions.

Specialties that will see the largest impact include cardiology, general surgery, and radiology; however, the update also includes many changes to CPT codes for vaccines/labs, telemedicine, remote patient monitoring (RPM), and more.

Here’s a brief summary of what to expect:

  • Cardiology: Several new Category III cardiology codes denote electrocardiogram and cardiac contractility modulation-defibrillator system.
  • General surgery: Several new codes (i.e., 15011-15018) reflect novel surgical approaches in skin grafts for wound care and recovery. There are also new codes for advancements in surgical techniques for the elimination of tumors within the abdomen (i.e., 49186-49190).
  • Radiology: Several new CPT codes denote magnetic resonance imaging (MRI)-monitored transurethral ultrasound ablation prostate, transcranial Doppler, percutaneous radiofrequency ablation of thyroid, fascial plane blocks, and magnetic resonance examination safety procedures. In addition, the 2025 CPT update converts MRI-guided high intensity-focused ultrasound from Category III to Category I. 
  • Vaccines/labs: The 2025 CPT update includes various changes to vaccination codes and proprietary laboratory analyses codes, including new codes for novel genetic testing. In addition, a new genetic counseling CPT code (96041) replaces 96040, and counselors can report it based on the total time they spend on the date of the encounter. "Face to face" is no longer in the code description.

Critical codes to watch

The 2025 CPT update includes several high-impact changes that may affect providers in multiple specialties. 

Here’s what you need to know:

  • RPM: Starting January 1, 2026, CPT code 98975 (RPM) also includes digital therapeutic intervention, while codes 98976-98978 (device supply) include devices for data access or data transmissions to support RPM. In addition, CPT code 98980 (RPM treatment management) requires only 11-20 minutes of a provider’s time rather than 20 minutes or more. For shorter-duration RPM, there are 6 new codes that cover the first 2 to 15 days (99XX4-99XX5 and 98XX4-98XX7). As the hospital-at-home movement continues to gain momentum, these codes can help providers get paid for their services, including RPM of various time durations. 
  • Telemedicine: Effective January 1, 2025, there are 17 new telemedicine codes, including audio-video visits for new patients (98000-98003) and audio-video visits for established patients (98004-98007). In addition, CPT 2025 deletes telephone-only codes 99441-99443 and replaces them with 98008-98011 (audio-only telemedicine visits for new patients) and 98012-98015 (audio-only telemedicine visits for established patients). In addition, new CPT code 98016 (virtual check-in) replaces HCPCS code G2012. As telemedicine continues to gain traction post-pandemic, these codes can help physicians increase access and gain new revenue.
  • Augmented/artificial intelligence (AI): CPT 2025 includes 7 additional Category III codes that describe augmentative data analysis using artificial intelligence, including 0877T-0880T (AI-powered analysis in medical chest imaging), 0902T-0932T (AI-augmented electrocardiogram data analysis), and 0898T (AI-augmented image-guided prostate biopsies). With the addition of these codes comes a growing awareness of the influence of AI in medicine.

It’s impossible to cover every CPT update in this article, which is why it’s important to review relevant sections in the 2025 CPT Coding Manual to ensure compliance in your medical practice. 

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Impact of the changes on medical billing and reimbursement

Reporting accurate CPT codes ensures revenue integrity for medical practices. It also reduces payer and provider rework.

When providers report the right medical codes, payers process those codes and pay medical claims as quickly as possible.

When providers report the right medical codes, payers process those codes and pay medical claims as quickly as possible. This saves time and reduces administrative costs for everyone. However, clinical documentation must also justify and support any CPT codes that providers assign. 

Here are 3 tips providers can use to promote compliance:

  1. Read the CPT code description in its entirety. Did you provide all components of the service? If so, ensure your clinical documentation reflects this. Be as specific as possible. For example, did you provide audio-only telemedicine, or was it audio-visual? Did you provide 3 days or 21 days of RPM? Did your analysis of a medical chest image include AI or not? These details matter.
  2. Document the patient’s diagnosis. Again, be as specific as possible. 
  3. Focus on medical necessity. Clearly explain to payers why the service was clinically necessary.
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Steps for implementing the 2025 CPT code update in medical practices

It’s always a good idea to dive into the CPT code changes as soon as possible. This gives ample time for medical coders, physicians, clinical documentation improvement specialists, and anyone else who uses medical codes on a regular basis to know what’s new, revised, and deleted. 

Here are 5 steps you can take now to ensure medical coding compliance.

  1. Purchase your 2025 CPT coding manual. Coding books and products are available from the AMA Storefront on Amazon, including the CPT 2025 Professional Edition codebook. CPT data products, including the CPT 2025 Standard Data File, are available via the AMA Intelligent Platform. Scan sections of the manual that pertain to your specialty so you can see what codes are new, revised, and deleted.
  2. Update coding tools and templates in your electronic health record (EHR). Communicate with your EHR vendor to ensure it automatically updates CPT changes for 2025, including adding new codes and deleting others. 
  3. Communicate with payers. Some payers may cover new CPT codes, while others may not. Know which payers cover which CPT codes for 2025 before you start submitting medical claims. And plan to monitor denials closely starting January 1.
  4. Educate staff. Participate in webinars to learn more about the 2025 CPT code updates and how they might affect medical practices. Education is the best way to avoid coding errors that may lead to claim rejections. 
  5. Ensure providers are in the loop. Providers don’t need to know all of the details pertaining to the 2025 CPT code update, but it’s probably a good idea to know which codes are no longer valid and which ones are new — especially for procedures reported most frequently.  

Conclusion: Staying ahead of CPT code updates

The AMA provides many resources and training opportunities for in-depth education about the 2025 CPT updates. Visit this site for more information. Also plan to attend the upcoming CPT & RBRVS 2025 Annual Symposium held virtually November 20-22, 2024. 

If you’re looking for additional resources, check out the meeting minutes from the September 2023 RVS update committee as well as the CPT editorial panel summary of panel actions from September 2024. Tebra also offers a free medical billing workbook that can help address CPT challenges.

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Lisa Eramo, freelance healthcare writer

Lisa A. Eramo, BA, MA is a freelance writer specializing in health information management, medical coding, and regulatory topics. She began her healthcare career as a referral specialist for a well-known cancer center. Lisa went on to work for several years at a healthcare publishing company. She regularly contributes to healthcare publications, websites, and blogs, including the AHIMA Journal. Her focus areas are medical coding, and ICD-10 in particular, clinical documentation improvement, and healthcare quality/efficiency.

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