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Dr. Starkman, the leading Neurologist in NYC, is the Medical Director and founder of New York Neurology Associates. He is Board Certified in Neurology with a subspecialty certification in Pain Medicine. Dr. Starkman is an Active Member of American Academy of Neurology, American Academy of Pain Medicine, International Spine Intervention Society, and American Society of Neuroimaging. He is an Assistant Clinical Professor at Columbia University Medical Center, and a Clinical Attending at Beth Israel Medical Center. Dr. Starkman was trained at Mount Sinai School of Medicine and Medical Center and has been practicing Neurology and Pain Medicine since 1996. He has implemented many new cutting edge approved therapies for various neurological and chronic painful conditions in his practice. Dr. Starkman was one of the pioneers who started to use Botox in chronic pain management, and one of the first doctors in New York who started to use radiofrequency ablation treatment for chronic spine joints pain. He was also one of the first 67 Neurologists in the USA who were trained and became Board certified in the subspecialty of Pain Medicine and has remained one of 31 such specialists in New York State as of 2014.

Dr. Starkman, the leading Neurologist in NYC, is the Medical Director and founder of New York Neurology Associates. He is Board Certified in Neurology with a subspecialty certification in Pain Medicine. Dr. Starkman is an Active Member of American Academy of Neurology, American Academy of Pain Medicine, International Spine Intervention Society, and American Society of Neuroimaging. He is an Assistant Clinical Professor at Columbia University Medical Center, and a Clinical Attending at Beth Israel Medical Center. Dr. Starkman was trained at Mount Sinai School of Medicine and Medical Center and has been practicing Neurology and Pain Medicine since 1996. He has implemented many new cutting edge approved therapies for various neurological and chronic painful conditions in his practice. Dr. Starkman was one of the pioneers who started to use Botox in chronic pain management, and one of the first doctors in New York who started to use radiofrequency ablation treatment for chronic spine joints pain. He was also one of the first 67 Neurologists in the USA who were trained and became Board certified in the subspecialty of Pain Medicine and has remained one of 31 such specialists in New York State as of 2014.

Nilufer Guleyupoglu, MD, is a specialist in helping people affected by pain and finding the most appropriate treatments for their individual situations. As owner and director of INVO Pain Medicine Group in Midtown, Manhattan, Dr. Guleyupoglu provides state-of-the-art facilities in her New York City office, including a fluoroscopy unit and ultrasound scanner on site. She has considerable expertise in physical medicine and rehabilitation and is committed to creating treatment plans that help ease the physical pain that affects so many men and women.

Dr. Guleyupoglu earned her medical degree from Istanbul University Cerrahpasa Medical School in 1988, after which she worked as a general practitioner and medical lecturer. After choosing to specialize in physical medicine and rehabilitation, she was awarded her fellowship in pain medicine from Mount Sinai Beth Israel Medical Center in 2004 and worked at the hospital for a further twelve years.

Both the American Board of Physical Medicine and Rehabilitation and the American Board of Pain Medicine certified Dr. Guleyupoglu as a specialist in the field of pain medicine, confirming her standing as a leading physician in her specialty. She has over thirty years of experience and has worked at some prestigious medical colleges and hospitals, including the Albert Einstein College of Medicine and New York University School of Medicine, both as a doctor and professor.

Making good use of her expertise in physical medicine and rehabilitation, Dr. Guleyupoglu specializes in treating people who are living with chronic pain, using a variety of techniques to improve quality of life for anyone who‘s struggling to manage their pain. She believes it’s vital to ensure that people receive all the information they need and are kept up-to-date concerning their treatments and any developments in the field of pain medicine. You can be sure of a warm and welcoming environment when you visit Dr. Guleyupoglu.

Dr. Guleyupoglu is also bilingual, speaking both English and Turkish.

Dr. Matthew A. Spiegel, an alumni of the NYU Grossman School of Medicine, completed an anesthesia residency at the NY-Presbyterian/Weill Cornell Medical Center, followed by a subspecialty fellowship in interventional pain management at Northwell Health. At Upper East Side Interventional Pain Management, Dr. Spiegel’s overriding goal is to ease and eliminate his patients’ pain. Dr. Spiegel’s expertise within interventional pain management encompasses a compassionate multimodal approach including conservative care, spinal/nerve/joint injections, neuromodulation, and advanced spine therapies. Rest assured, Dr. Spiegel will deal with your pain as if it is his own.

Dr. Starkman, the leading Neurologist in NYC, is the Medical Director and founder of New York Neurology Associates. He is Board Certified in Neurology with a subspecialty certification in Pain Medicine. Dr. Starkman is an Active Member of American Academy of Neurology, American Academy of Pain Medicine, International Spine Intervention Society, and American Society of Neuroimaging. He is an Assistant Clinical Professor at Columbia University Medical Center, and a Clinical Attending at Beth Israel Medical Center. Dr. Starkman was trained at Mount Sinai School of Medicine and Medical Center and has been practicing Neurology and Pain Medicine since 1996. He has implemented many new cutting edge approved therapies for various neurological and chronic painful conditions in his practice. Dr. Starkman was one of the pioneers who started to use Botox in chronic pain management, and one of the first doctors in New York who started to use radiofrequency ablation treatment for chronic spine joints pain. He was also one of the first 67 Neurologists in the USA who were trained and became Board certified in the subspecialty of Pain Medicine and has remained one of 31 such specialists in New York State as of 2014.

Dr. Starkman, the leading Neurologist in NYC, is the Medical Director and founder of New York Neurology Associates. He is Board Certified in Neurology with a subspecialty certification in Pain Medicine. Dr. Starkman is an Active Member of American Academy of Neurology, American Academy of Pain Medicine, International Spine Intervention Society, and American Society of Neuroimaging. He is an Assistant Clinical Professor at Columbia University Medical Center, and a Clinical Attending at Beth Israel Medical Center. Dr. Starkman was trained at Mount Sinai School of Medicine and Medical Center and has been practicing Neurology and Pain Medicine since 1996. He has implemented many new cutting edge approved therapies for various neurological and chronic painful conditions in his practice. Dr. Starkman was one of the pioneers who started to use Botox in chronic pain management, and one of the first doctors in New York who started to use radiofrequency ablation treatment for chronic spine joints pain. He was also one of the first 67 Neurologists in the USA who were trained and became Board certified in the subspecialty of Pain Medicine and has remained one of 31 such specialists in New York State as of 2014.

Sumeet Arora, MD, who is board-certified in both Anesthesiology and Pain Medicine, brings knowledge and refreshing insight to the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He recently became credentialed by the International Society for Stem Cell Application in cellular-based products for regenerative medicine and is a member of the society. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey, and Staten Island and Ardsley, New York.

Dr. Arora graduated from Binghamton University in New York. After undergrad, he traveled to Philadelphia to attend Drexel University College of Medicine, where he conducted medical research and earned his Masters of Medical Science. Dr. Arora then returned to New York for medical school at New York College of Osteopathic Medicine.

After medical school, Dr. Arora completed his residency in Anesthesiology and a clinical fellowship in pain medicine through the Icahn School of Medicine at Mount Sinai Roosevelt and Mount Sinai St. Luke’s, both in New York City. During his education, Dr. Arora received recognition and numerous awards for his excellence in learning and practice.

Dr. Arora brings vast experience and up-to-date knowledge to the team of doctors and professionals at Metro Pain and Vein Centers. He believes in treating his patients with comfort, compassion, and communication. As a partner in his patient’s health, he is committed to understanding the goals of his patients and believes this is the key to the best clinical results.

As a board-certified anesthesiologist and doctor of osteopathy, Rahul Sood, DO, is an integral part of the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey; and Staten Island and Ardsley, New York.

Dr. Sood received a degree in pharmaceutical medicine from Rutgers University in New Brunswick, New Jersey. He received his certification as a doctor of osteopathy at Lake Erie College of Osteopathic Medicine.

He returned to Rutgers for his residency in Anesthesiology and fellowship training in Interventional Pain Medicine, gaining valuable experience at Robert Wood Johnson University Hospital in New Brunswick, New Jersey.

Dr. Sood is a double board-certified Diplomate of the American Board of Anesthesiology and is also certified in Pain Medicine. He is the Chairman of Anesthesiology at New Bridge Medical Center. His extensive education and nearly 10 years of professional experience in private practice have given Dr. Sood a passion for treating complicated pain issues. His specific interests include pain related to nerve problems, sports injuries, and cancer. His pharmacy background has proven to be an asset while managing intractable pain. Dr. Sood is also skilled in treatment for unsightly and painful varicose veins, including sclerotherapy and vein ablation.

Dr. Sood has been concentrating on finding new ways to improve his patient’s quality of life through regenerative medicine. He feels that platelet-rich plasma therapy and stem cell treatments will be monumental in the future of medicine.

Dr. Sood continues to add to his education, staying up-to-date on the latest techniques and methods for anesthesiology and pain medicine. He writes professionally, gives lectures, and has contributed to presentations at Westchester Medical Center in Valhalla, New York, on the topic of interventional techniques in pain medicine.

Speaking four different languages — English, Spanish, Punjabi, and Hindi — Dr. Sood believes in open communication and in nurturing honest and forthright relationships. He strives to give compassionate, knowledgeable, and personalized care to all of his patients.

In his free time, Dr. Sood enjoys spending time with his family and participating in a variety of sports activities.

As a medical doctor and anesthesiologist, Sachin Shah, MD, is a valuable asset to the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He recently became credentialed by the International Society for Stem Cell Application in cellular-based products for regenerative medicine and is a member of the society. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey; and Staten Island and Ardsley, New York. 

Dr. Shah earned his medical degree from the State University of New York in Syracuse, New York. Dr. Shah went on to complete his residency in Anesthesiology and fellowship in Pain Medicine at New York University Langone Medical Center in New York City.

Dr. Shah is a double board-certified Diplomate of the American Board of Anesthesiology and is also certified in Pain Medicine. He stays up-to-date on the latest treatments in medicine, anesthesiology, and pain management. Recently, Dr. Shah has been focusing on regenerative medicine as a way to optimize the quality of life for his patients. He believes that platelet-rich plasma therapy and stem cell treatments hold great promise for the future of medicine.

With a goal of improving the lives of his patient’s using evidence-based medicine, Dr. Shah incorporates a multi-modal approach in his treatments for managing acute, chronic pain, and cancer pain as well treatments of varicose veins. He may recommend treatments that include interventional procedures, pharmacotherapy, lifestyle modification, chiropractic care, acupuncture, and physical therapy.

Since beginning practice nearly five years ago, Dr. Shah has been committed to building strong relationships with his patients. He speaks four languages — English, Spanish, Hindi, and Gujarati — which he utilizes to connect with patients of various backgrounds and cultures.

In his free time, Dr. Shah enjoys traveling, watching college basketball, and spending time with his wife and daughters. He currently lives in Northern New Jersey.

Dr. Dev Sinha specializes in pain medicine and physical medicine and rehabilitation at Garden State Pain & Orthopedics. He uses a comprehensive approach when treating pain, integrating physical and behavioral therapies, medications, and the most innovative, minimally-invasive procedures. He believes in offering alternative medicine therapies for the treatment of difficult-to-treat pain conditions. His expert care is available at four convenient locations in Edison, Clifton, West Orange, and Jersey City, New Jersey.

Dr. Sinha attended George Washington University, then earned his Doctor of Medicine from American University of Antigua College of Medicine. He went on to complete his residency and fellowship training in interventional pain medicine at the prestigious University of Pennsylvania in Philadelphia.

During his fellowship at the University of Pennsylvania, he trained with the top physicians in the field of pain management. His dedication to the advancement of the field can be seen through his numerous publications that contribute to the study and treatment of pain medicine.

Dr. Sinha lives in New Jersey with his wife, Arpita, and son and daughter. When he’s not in the office, his interests include reading, tennis, skiing, and cooking.

Double board-certified Aditya Patel, MD, of Sports, Pain & Regenerative Institute, is an anesthesiologist and interventional pain medicine specialist offering innovative and effective treatments in Fairview, New Jersey. Dr. Patel specializes in non-surgical treatments for all types of acute and chronic pain, including sports injuries. Dr. Patel earned his bachelor’s degree in physiology and neuroscience from the University of California, San Diego, followed by his medical degree with high honors from St. George’s University School of Medicine in St. George’s, Grenada.

Dr. Patel completed his residency in anesthesiology at the Cooperman Barnabas Medical Center in Livingston, New Jersey, where he was chief resident during his final year. During his residency, Dr. Patel developed a particular interest in interventional pain medicine and regional anesthesia. He had the opportunity to pursue his interests when he attended the Icahn School of Medicine at Mount Sinai, New York City, for his postgraduate fellowship in interventional pain management. After finishing his fellowship training, Dr. Patel became an anesthesiologist at New York City’s Mount Sinai Brooklyn hospital before moving to private practice.Dr. Patel’s passions include office-based diagnostics and therapeutic interventions with multidisciplinary physical medicine treatments to achieve optimal results for his patients. Dr. Patel is continually seeking new treatment options for his patients, such as the use of biologics, like platelet-rich plasma (PRP), to reduce pain and restore function. He has also undergone specialized training in the most advanced, up-to-date, and minimally invasive treatments. Dr. Patel’s patients appreciate his thoroughness, the time he spends with them, and his ability to provide them with the information they need. Dr. Patel delivers exceptional care that relieves even the most persistent pain.

SamWell Institute for Pain Management is a premier  interventional pain specialty practice led by Jay Shah, MD and his highly trained team. With offices in Colonia, Englewood, Ridgewood, and Livingston, New Jersey, they offer long-term, interventional pain-relieving solutions that focus on non-opioid and nonsurgical interventional treatments for spine and orthopedic conditions.

Through novel, non-surgical, and minimally invasive interventional techniques, our interventional pain specialists utilize the latest technologies to help restore and maximize function and quality of life of patients with chronic musculoskeletal pain related to degenerative conditions as well as sports-related or traumatic injuries.

Our treatments include non-surgical orthopedic procedures for disc herniation‘s in the neck and back, low back and sciatica pain, neck, knee, shoulder, and hip pain as well as nerve pain after neck or back surgeries. We also specialize in interventional approaches for severe chronic migraine/headaches, chronic pelvic pain, facial pain, and severe nerve and neuropathy pain.

At SamWell pain, we are spine, joint, and nerve pain specialists, whose expertise includes non-surgical and non-opioid pain relieving treatments performed under precise image guidance, such as spinal cord stimulation and Dorsal Root Ganglion Stimulation for complex nerve pain disorders including CRPS/RSD, and minimally invasive therapies such as MILD, Vertiflex, Kyphoplasty, Sacroiliac joint fusion, and Endoscopic procedures.

We also specialize in epidural steroid injections for discreations in the neck and back, spinal facet join treatments, radiofrequency ablations, nerve blocks and joint procedures for cervical and lumbar spinal stenosis.

Dr. Starkman, the leading Neurologist in NYC, is the Medical Director and founder of New York Neurology Associates. He is Board Certified in Neurology with a subspecialty certification in Pain Medicine. Dr. Starkman is an Active Member of American Academy of Neurology, American Academy of Pain Medicine, International Spine Intervention Society, and American Society of Neuroimaging. He is an Assistant Clinical Professor at Columbia University Medical Center, and a Clinical Attending at Beth Israel Medical Center. Dr. Starkman was trained at Mount Sinai School of Medicine and Medical Center and has been practicing Neurology and Pain Medicine since 1996. He has implemented many new cutting edge approved therapies for various neurological and chronic painful conditions in his practice. Dr. Starkman was one of the pioneers who started to use Botox in chronic pain management, and one of the first doctors in New York who started to use radiofrequency ablation treatment for chronic spine joints pain. He was also one of the first 67 Neurologists in the USA who were trained and became Board certified in the subspecialty of Pain Medicine and has remained one of 31 such specialists in New York State as of 2014.

Sumeet Arora, MD, who is board-certified in both Anesthesiology and Pain Medicine, brings knowledge and refreshing insight to the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He recently became credentialed by the International Society for Stem Cell Application in cellular-based products for regenerative medicine and is a member of the society. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey, and Staten Island and Ardsley, New York.

Dr. Arora graduated from Binghamton University in New York. After undergrad, he traveled to Philadelphia to attend Drexel University College of Medicine, where he conducted medical research and earned his Masters of Medical Science. Dr. Arora then returned to New York for medical school at New York College of Osteopathic Medicine.

After medical school, Dr. Arora completed his residency in Anesthesiology and a clinical fellowship in pain medicine through the Icahn School of Medicine at Mount Sinai Roosevelt and Mount Sinai St. Luke’s, both in New York City. During his education, Dr. Arora received recognition and numerous awards for his excellence in learning and practice.

Dr. Arora brings vast experience and up-to-date knowledge to the team of doctors and professionals at Metro Pain and Vein Centers. He believes in treating his patients with comfort, compassion, and communication. As a partner in his patient’s health, he is committed to understanding the goals of his patients and believes this is the key to the best clinical results.

As a medical doctor and anesthesiologist, Sachin Shah, MD, is a valuable asset to the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He recently became credentialed by the International Society for Stem Cell Application in cellular-based products for regenerative medicine and is a member of the society. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey; and Staten Island and Ardsley, New York. 

Dr. Shah earned his medical degree from the State University of New York in Syracuse, New York. Dr. Shah went on to complete his residency in Anesthesiology and fellowship in Pain Medicine at New York University Langone Medical Center in New York City.

Dr. Shah is a double board-certified Diplomate of the American Board of Anesthesiology and is also certified in Pain Medicine. He stays up-to-date on the latest treatments in medicine, anesthesiology, and pain management. Recently, Dr. Shah has been focusing on regenerative medicine as a way to optimize the quality of life for his patients. He believes that platelet-rich plasma therapy and stem cell treatments hold great promise for the future of medicine.

With a goal of improving the lives of his patient’s using evidence-based medicine, Dr. Shah incorporates a multi-modal approach in his treatments for managing acute, chronic pain, and cancer pain as well treatments of varicose veins. He may recommend treatments that include interventional procedures, pharmacotherapy, lifestyle modification, chiropractic care, acupuncture, and physical therapy.

Since beginning practice nearly five years ago, Dr. Shah has been committed to building strong relationships with his patients. He speaks four languages — English, Spanish, Hindi, and Gujarati — which he utilizes to connect with patients of various backgrounds and cultures.

In his free time, Dr. Shah enjoys traveling, watching college basketball, and spending time with his wife and daughters. He currently lives in Northern New Jersey.

As a board-certified anesthesiologist and doctor of osteopathy, Rahul Sood, DO, is an integral part of the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey; and Staten Island and Ardsley, New York.

Dr. Sood received a degree in pharmaceutical medicine from Rutgers University in New Brunswick, New Jersey. He received his certification as a doctor of osteopathy at Lake Erie College of Osteopathic Medicine.

He returned to Rutgers for his residency in Anesthesiology and fellowship training in Interventional Pain Medicine, gaining valuable experience at Robert Wood Johnson University Hospital in New Brunswick, New Jersey.

Dr. Sood is a double board-certified Diplomate of the American Board of Anesthesiology and is also certified in Pain Medicine. He is the Chairman of Anesthesiology at New Bridge Medical Center. His extensive education and nearly 10 years of professional experience in private practice have given Dr. Sood a passion for treating complicated pain issues. His specific interests include pain related to nerve problems, sports injuries, and cancer. His pharmacy background has proven to be an asset while managing intractable pain. Dr. Sood is also skilled in treatment for unsightly and painful varicose veins, including sclerotherapy and vein ablation.

Dr. Sood has been concentrating on finding new ways to improve his patient’s quality of life through regenerative medicine. He feels that platelet-rich plasma therapy and stem cell treatments will be monumental in the future of medicine.

Dr. Sood continues to add to his education, staying up-to-date on the latest techniques and methods for anesthesiology and pain medicine. He writes professionally, gives lectures, and has contributed to presentations at Westchester Medical Center in Valhalla, New York, on the topic of interventional techniques in pain medicine.

Speaking four different languages — English, Spanish, Punjabi, and Hindi — Dr. Sood believes in open communication and in nurturing honest and forthright relationships. He strives to give compassionate, knowledgeable, and personalized care to all of his patients.

In his free time, Dr. Sood enjoys spending time with his family and participating in a variety of sports activities.

As a board-certified anesthesiologist and doctor of osteopathy, Rahul Sood, DO, is an integral part of the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey; and Staten Island and Ardsley, New York.

Dr. Sood received a degree in pharmaceutical medicine from Rutgers University in New Brunswick, New Jersey. He received his certification as a doctor of osteopathy at Lake Erie College of Osteopathic Medicine.

He returned to Rutgers for his residency in Anesthesiology and fellowship training in Interventional Pain Medicine, gaining valuable experience at Robert Wood Johnson University Hospital in New Brunswick, New Jersey.

Dr. Sood is a double board-certified Diplomate of the American Board of Anesthesiology and is also certified in Pain Medicine. He is the Chairman of Anesthesiology at New Bridge Medical Center. His extensive education and nearly 10 years of professional experience in private practice have given Dr. Sood a passion for treating complicated pain issues. His specific interests include pain related to nerve problems, sports injuries, and cancer. His pharmacy background has proven to be an asset while managing intractable pain. Dr. Sood is also skilled in treatment for unsightly and painful varicose veins, including sclerotherapy and vein ablation.

Dr. Sood has been concentrating on finding new ways to improve his patient’s quality of life through regenerative medicine. He feels that platelet-rich plasma therapy and stem cell treatments will be monumental in the future of medicine.

Dr. Sood continues to add to his education, staying up-to-date on the latest techniques and methods for anesthesiology and pain medicine. He writes professionally, gives lectures, and has contributed to presentations at Westchester Medical Center in Valhalla, New York, on the topic of interventional techniques in pain medicine.

Speaking four different languages — English, Spanish, Punjabi, and Hindi — Dr. Sood believes in open communication and in nurturing honest and forthright relationships. He strives to give compassionate, knowledgeable, and personalized care to all of his patients.

In his free time, Dr. Sood enjoys spending time with his family and participating in a variety of sports activities.

Sumeet Arora, MD, who is board-certified in both Anesthesiology and Pain Medicine, brings knowledge and refreshing insight to the team at Metro Pain and Vein Centers. He is also a specialist and venous medicine with an extensive history and experience in treating lower extremity spider and varicose veins. He recently became credentialed by the International Society for Stem Cell Application in cellular-based products for regenerative medicine and is a member of the society. He practices from the offices in Clifton, Middletown, Riverdale, Edison, and Jersey City, New Jersey, and Staten Island and Ardsley, New York.

Dr. Arora graduated from Binghamton University in New York. After undergrad, he traveled to Philadelphia to attend Drexel University College of Medicine, where he conducted medical research and earned his Masters of Medical Science. Dr. Arora then returned to New York for medical school at New York College of Osteopathic Medicine.

After medical school, Dr. Arora completed his residency in Anesthesiology and a clinical fellowship in pain medicine through the Icahn School of Medicine at Mount Sinai Roosevelt and Mount Sinai St. Luke’s, both in New York City. During his education, Dr. Arora received recognition and numerous awards for his excellence in learning and practice.

Dr. Arora brings vast experience and up-to-date knowledge to the team of doctors and professionals at Metro Pain and Vein Centers. He believes in treating his patients with comfort, compassion, and communication. As a partner in his patient’s health, he is committed to understanding the goals of his patients and believes this is the key to the best clinical results.